Determinants of cation transport selectivity: Equilibrium binding and transport kinetics.
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ABSTRACT:
SUBMITTER: Lockless SW
PROVIDER: S-EPMC4485025 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Determinants of cation transport selectivity: Equilibrium binding and transport kinetics.
The Journal of general physiology 20150615 1
The crystal structures of channels and transporters reveal the chemical nature of ion-binding sites and, thereby, constrain mechanistic models for their transport processes. However, these structures, in and of themselves, do not reveal equilibrium selectivity or transport preferences, which can be discerned only from various functional assays. In this Review, I explore the relationship between cation transport protein structures, equilibrium binding measurements, and ion transport selectivity. ...[more]
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