Ontology highlight
ABSTRACT:
SUBMITTER: Brousse V
PROVIDER: S-EPMC4485482 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
EBioMedicine 20141218 2
Sickle cell anaemia (SCA) results from a single mutation in the β globin gene. It is seldom symptomatic in the first semester of life. We analysed the expression pattern of 9 adhesion molecules on red blood cells, in a cohort of 54 SCA and 17 non-SCA very young infants of comparable age (median 144 days, 81-196). Haemoglobin F (HbF) level was unsurprisingly elevated in SCA infants (41.2% ± 11.2) and 2-4 fold higher than in non-SCA infants, yet SCA infants presented significantly decreased Hb lev ...[more]