Ontology highlight
ABSTRACT:
SUBMITTER: Housseau F
PROVIDER: S-EPMC4485714 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Housseau Franck F Llosa Nicolas J NJ
Oncoimmunology 20150319 6
The active Th1/CTL immune microenvironment of Microsatellite Instable colorectal cancer (CRC) is counterbalanced by up-regulated expression of multiple immune checkpoints, suggesting that defective mismatch repair may be a biomarker to select CRC patients for treatment with checkpoint inhibitors. This hypothesis is currently being tested in two clinical trials. ...[more]