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Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinic.


ABSTRACT: The active Th1/CTL immune microenvironment of Microsatellite Instable colorectal cancer (CRC) is counterbalanced by up-regulated expression of multiple immune checkpoints, suggesting that defective mismatch repair may be a biomarker to select CRC patients for treatment with checkpoint inhibitors. This hypothesis is currently being tested in two clinical trials.

SUBMITTER: Housseau F 

PROVIDER: S-EPMC4485714 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinic.

Housseau Franck F   Llosa Nicolas J NJ  

Oncoimmunology 20150319 6


The active Th1/CTL immune microenvironment of Microsatellite Instable colorectal cancer (CRC) is counterbalanced by up-regulated expression of multiple immune checkpoints, suggesting that defective mismatch repair may be a biomarker to select CRC patients for treatment with checkpoint inhibitors. This hypothesis is currently being tested in two clinical trials. ...[more]

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