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Improving clinical benefit for prostate cancer patients through the combination of androgen deprivation and immunotherapy.


ABSTRACT: Androgen-deprivation therapy (ADT) induces prostate cancer immunogenic modulation (IM) by reducing human tumor cell expression of anti-apoptotic genes thus facilitating increased sensitivity to immune-mediated lysis. Through its stimulation of IM, ADT has been shown to synergize with active immunotherapy thereby significantly improving overall survival in a mouse model of prostate cancer.

SUBMITTER: Kwilas AR 

PROVIDER: S-EPMC4485836 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Improving clinical benefit for prostate cancer patients through the combination of androgen deprivation and immunotherapy.

Kwilas Anna R AR   Gameiro Sofia R SR   Kim Peter S PS   Malamas Anthony S AS   Hodge James W JW  

Oncoimmunology 20150302 6


Androgen-deprivation therapy (ADT) induces prostate cancer immunogenic modulation (IM) by reducing human tumor cell expression of anti-apoptotic genes thus facilitating increased sensitivity to immune-mediated lysis. Through its stimulation of IM, ADT has been shown to synergize with active immunotherapy thereby significantly improving overall survival in a mouse model of prostate cancer. ...[more]

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