Improving clinical benefit for prostate cancer patients through the combination of androgen deprivation and immunotherapy.
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ABSTRACT:
SUBMITTER: Kwilas AR
PROVIDER: S-EPMC4485836 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Improving clinical benefit for prostate cancer patients through the combination of androgen deprivation and immunotherapy.
Kwilas Anna R AR Gameiro Sofia R SR Kim Peter S PS Malamas Anthony S AS Hodge James W JW
Oncoimmunology 20150302 6
Androgen-deprivation therapy (ADT) induces prostate cancer immunogenic modulation (IM) by reducing human tumor cell expression of anti-apoptotic genes thus facilitating increased sensitivity to immune-mediated lysis. Through its stimulation of IM, ADT has been shown to synergize with active immunotherapy thereby significantly improving overall survival in a mouse model of prostate cancer. ...[more]
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