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Development of adrenal cortex zonation.

ABSTRACT: The human adult adrenal cortex is composed of the zona glomerulosa (zG), zona fasciculata (zF), and zona reticularis (zR), which are responsible for production of mineralocorticoids, glucocorticoids, and adrenal androgens, respectively. The final completion of cortical zonation in humans does not occur until puberty with the establishment of the zR and its production of adrenal androgens; a process called adrenarche. The maintenance of the adrenal cortex involves the centripetal displacement and differentiation of peripheral Sonic hedgehog-positive progenitors cells into zG cells that later transition to zF cells and subsequently zR cells.

SUBMITTER: Xing Y

PROVIDER: S-EPMC4486052 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Development of adrenal cortex zonation.

Xing Yewei Y Lerario Antonio M AM Rainey William W Hammer Gary D GD

Endocrinology and metabolism clinics of North America 20150601 2

The human adult adrenal cortex is composed of the zona glomerulosa (zG), zona fasciculata (zF), and zona reticularis (zR), which are responsible for production of mineralocorticoids, glucocorticoids, and adrenal androgens, respectively. The final completion of cortical zonation in humans does not occur until puberty with the establishment of the zR and its production of adrenal androgens; a process called adrenarche. The maintenance of the adrenal cortex involves the centripetal displacement and ...[more]

PMID: 26038200

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