Ontology highlight
ABSTRACT:
SUBMITTER: Choi SJ
PROVIDER: S-EPMC4486152 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Choi Su Jin SJ Jang Ki Jung KJ Lim Jeong-A JA Kim Hye Sun HS
Blood research 20150625 2
<h4>Background</h4>Hemophilia A is caused by heterogeneous mutations in F8. Coagulation factor VIII (FVIII), the product of F8, is composed of multiple domains designated A1-A2-B-A3-C1-C2. FVIII is known to interact with diverse proteins, and this characteristic may be important for hemostasis. However, little is known about domain-specific functions or their specific binding partners.<h4>Methods</h4>To determine F8 domain-specific functions during blood coagulation, the FVIII domains A1, A2, A3 ...[more]