Ontology highlight
ABSTRACT:
SUBMITTER: Jabbari A
PROVIDER: S-EPMC4486197 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Jabbari Ali A Dai Zhenpeng Z Xing Luzhou L Cerise Jane E JE Ramot Yuval Y Berkun Yackov Y Sanchez Gina A Montealegre GA Goldbach-Mansky Raphaela R Christiano Angela M AM Clynes Raphael R Zlotogorski Abraham A
EBioMedicine 20150226 4
<h4>Background</h4>Alopecia areata (AA) is an autoimmune disease resulting in hair loss with devastating psychosocial consequences. Despite its high prevalence, there are no FDA-approved treatments for AA. Prior studies have identified a prominent interferon signature in AA, which signals through JAK molecules.<h4>Methods</h4>A patient with AA was enrolled in a clinical trial to examine the efficacy of baricitinib, a JAK1/2 inhibitor, to treat concomitant CANDLE syndrome. In vivo, preclinical st ...[more]