Ontology highlight
ABSTRACT:
SUBMITTER: Whelan R
PROVIDER: S-EPMC4486207 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Whelan Robert R Watts Richard R Orr Catherine A CA Althoff Robert R RR Artiges Eric E Banaschewski Tobias T Barker Gareth J GJ Bokde Arun L W AL Büchel Christian C Carvalho Fabiana M FM Conrod Patricia J PJ Flor Herta H Fauth-Bühler Mira M Frouin Vincent V Gallinat Juergen J Gan Gabriela G Gowland Penny P Heinz Andreas A Ittermann Bernd B Lawrence Claire C Mann Karl K Martinot Jean-Luc JL Nees Frauke F Ortiz Nick N Paillère-Martinot Marie-Laure ML Paus Tomas T Pausova Zdenka Z Rietschel Marcella M Robbins Trevor W TW Smolka Michael N MN Ströhle Andreas A Schumann Gunter G Garavan Hugh H
Nature 20140702 7513
A comprehensive account of the causes of alcohol misuse must accommodate individual differences in biology, psychology and environment, and must disentangle cause and effect. Animal models can demonstrate the effects of neurotoxic substances; however, they provide limited insight into the psycho-social and higher cognitive factors involved in the initiation of substance use and progression to misuse. One can search for pre-existing risk factors by testing for endophenotypic biomarkers in non-usi ...[more]