Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide.
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ABSTRACT:
SUBMITTER: Thompson P
PROVIDER: S-EPMC4486256 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide.
Thompson Pamela P Lakshminarayanan Vani V Supekar Nitin T NT Bradley Judy M JM Cohen Peter A PA Wolfert Margreet A MA Gendler Sandra J SJ Boons Geert-Jan GJ
Chemical communications (Cambridge, England) 20150529 50
A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1. ...[more]
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