Ontology highlight
ABSTRACT:
SUBMITTER: Scotti M
PROVIDER: S-EPMC4486385 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Scotti Martina M Kherdjemil Yacine Y Roux Marine M Kmita Marie M
Genesis (New York, N.Y. : 2000) 20150530 6
The developing limb is a useful model for studying organogenesis and developmental processes. Although Cre alleles exist for conditional loss- or gain-of-function in limbs, Cre alleles targeting specific limb subdomains are desirable. Here we report on the generation of the Hoxa13:Cre line, in which the Cre gene is inserted in the endogenous Hoxa13 gene. We provide evidence that the Cre is active in embryonic tissues/regions where the endogenous Hoxa13 gene is expressed. Our results show that ce ...[more]