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A systematic analysis of human lipocalin family and its expression in esophageal carcinoma.


ABSTRACT: The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been found to play important roles in many human diseases. For this reason, a systemic analysis of the molecular properties of human lipocalins is essential. In this study, human lipocalins were found to contain four structurally conserved regions (SCRs) and could be divided into two subgroups. A human lipocalin protein-protein interaction network (PPIN) was constructed and integrated with their expression data in esophageal carcinoma. Many lipocalins showed obvious co-expression patterns in esophageal carcinoma. Their subcellular distributions also suggested these lipocalins may transfer signals from the extracellular space to the nucleus using the pathway-like paths. These analyses also expanded our knowledge about this human ancient protein family in the background of esophageal carcinoma.

SUBMITTER: Du ZP 

PROVIDER: S-EPMC4487233 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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A systematic analysis of human lipocalin family and its expression in esophageal carcinoma.

Du Ze-Peng ZP   Wu Bing-Li BL   Wu Xuan X   Lin Xuan-Hao XH   Qiu Xiao-Yang XY   Zhan Xiao-Fen XF   Wang Shao-Hong SH   Shen Jin-Hui JH   Zheng Chun-Peng CP   Wu Zhi-Yong ZY   Xu Li-Yan LY   Wang Dong D   Li En-Min EM  

Scientific reports 20150701


The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been found to play important roles in many human diseases. For this reason, a systemic analysis of the molecular properties of human lipocalins is essential. In this study, human lipocalins were found to contain four structurally conserved regions (SCRs) and could be divided into two subgroups. A human lipocalin protein-protein  ...[more]

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