Targeting the inflammasome in rheumatic diseases.
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ABSTRACT:
SUBMITTER: McCoy SS
PROVIDER: S-EPMC4487391 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Targeting the inflammasome in rheumatic diseases.
McCoy Sara S SS Stannard Jasmine J Kahlenberg J Michelle JM
Translational research : the journal of laboratory and clinical medicine 20150611 1
Activation of the inflammasome, a protein complex responsible for many cellular functions, including the activation of the proinflammatory cytokines interleukin (IL)-1β and IL-18, has been identified as a key participant in many rheumatic diseases including autoimmune, inflammatory, and autoinflammatory syndromes. This review will discuss the recent advances in understanding the role of this complex in various rheumatic diseases. Furthermore, it will focus on available therapies, which directly ...[more]
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