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Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review.


ABSTRACT:

Background

To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT). The use of topical drugs, which are able to reduce mucosal inflammation and to improve healing tissues, can represent a relevant therapeutic advance. Topical sodium hyaluronate (SH) has recently been recognized as adjuvant treatment in the chronic inflammatory disease of the UADT.

Aims

The aim of our work was to review the published literature regarding all the potential therapeutic effects of SH in the chronic inflammatory disease of UADT.

Methods

Relevant published studies were searched in Pubmed, Google Scholar, Ovid using keywords ("sodium hyaluronate" and "upper airways") or Medical Subject Headings.

Results

At the end of our selection process, sixteen publications have been included. Six of them in the post-operative period of nasal-sinus surgery, 2 of them in pediatric patients affected by recurrent upper respiratory tract infections, 4 of them in reducing symptoms and preventing exacerbations of chronic upper airways in adult population, 4 of them in patients with chronic inflammatory disease of UADT, including gastro-esophageal reflux disease (GERD).

Conclusions

Topical administration of SH plays a pivotkey role in the postoperative phase of patients undergoing FESS and nasal surgery, and positive results are generally observed in all the patients suffering from UADT chronic inflammatory disease.

SUBMITTER: Casale M 

PROVIDER: S-EPMC4487693 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review.

Casale Manuele M   Moffa Antonio A   Sabatino Lorenzo L   Pace Annalisa A   Oliveto Giuseppe G   Vitali Massimiliano M   Baptista Peter P   Salvinelli Fabrizio F  

PloS one 20150629 6


<h4>Background</h4>To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT). The use of topical drugs, which are able to reduce mucosal inflammation and to improve healing tissues, can represent a relevant therapeutic advance. Topical sodium hyaluronate (SH) has recently been recognized as adjuvant treatment in the chronic inflammatory disease of the UADT.<h4>Aims</h4>The aim of our work was to rev  ...[more]

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