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Theoretical aspects of immunity.

ABSTRACT: The immune system recognizes a myriad of invading pathogens and their toxic products. It does so with a finite repertoire of antibodies and T cell receptors. We here describe theories that quantify the dynamics of the immune system. We describe how the immune system recognizes antigens by searching the large space of receptor molecules. We consider in some detail the theories that quantify the immune response to influenza and dengue fever. We review theoretical descriptions of the complementary evolution of pathogens that occurs in response to immune system pressure. Methods including bioinformatics, molecular simulation, random energy models, and quantum field theory contribute to a theoretical understanding of aspects of immunity.

SUBMITTER: Deem MW

PROVIDER: S-EPMC4487771 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Theoretical aspects of immunity.

Deem Michael W MW Hejazi Pooya P

Annual review of chemical and biomolecular engineering 20100101

The immune system recognizes a myriad of invading pathogens and their toxic products. It does so with a finite repertoire of antibodies and T cell receptors. We here describe theories that quantify the dynamics of the immune system. We describe how the immune system recognizes antigens by searching the large space of receptor molecules. We consider in some detail the theories that quantify the immune response to influenza and dengue fever. We review theoretical descriptions of the complementary ...[more]

PMID: 22432581

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