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A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population.

ABSTRACT: BACKGROUND:Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis. METHODS:Search the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population and Chinese population under an additive genetic model by STATA11.0. RESULTS:The pooled odds ratios (OR) of rs12979860 are 0.79 (95% CI, 0.53-1.18; P = 0.25, I(2)?= 63.2%) and 1.62 (95% CI, 1.04-2.51; P = 0.033, I(2) = 54.3%) respectively in Asian population and Chinese population analysis. The pooled OR of rs8099917 are 1.05 (95% CI, 0.93-1.19; P = 0.44, I(2)?= 43.3%) and 0.97 (95% CI, 0.84-1.23; P = 0.726, I(2)?= 15.6%) respectively in Asian population and Chinese population analysis. CONCLUSION:Our study demonstrated that T allele of rs12979680 can increase the risk of HBV infection in Chinese population but not Asian population under an additive genetic model. There is no association between rs8099917 and HBV infection in Chinese population and Asian population.

SUBMITTER: Chen J

PROVIDER: S-EPMC4488117 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population.

Chen Jing J Wang Wei W Li Xiaoguang X Xu Jie J

BMC gastroenterology 20150512

<h4>Background</h4>Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis.<h4>Methods</h4>Search the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population an ...[more]

PMID: 25962810

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Project description:BACKGROUND:Recent clinical studies have shown that the presence of CC genotype in the rs12979860 region of IL28B gene is associated with an increase in the probability of spontaneous clearance of hepatitis C virus (HCV). Moreover, IL28B polymorphism seems to influence the probability of developing liver steatosis in chronic HCV patients. AIMS:The aims of our clinical study were 1) to verify the distribution of IL28B genotypes (CC, CT or TT) among subjects with spontaneous clearance of HCV infection and 2) to examine the correlation between IL28B polymorphism and hepatic steatosis among these subjects. METHODS AND PATIENTS:We enrolled 41 subjects with spontaneous resolution of HCV infection (detectable serum anti-HCV but undetectable HCV-RNA) and 134 healthy controls from the same geographical area. The IL28B single-nucleotide polymorphism (SNP) rs12979860 was genotyped by using a Pyrosequencing™ technique. The presence of steatosis was assessed by liver biopsy or ultrasound examination in the 41 study subjects. RESULTS:CC, CT and TT-genotypes of the SNP rs1979860 were found in 66%, 24% and 10% of the subjects who spontaneously cleared HCV and in 31%, 54% and 15% of controls, respectively (p?=?0.0003). Among the study subjects, females with CC-genotype were significantly more represented (p?=?0.02). Hepatic steatosis did not correlate with IL28B genotype (p?=?0,14) but only with a high body mass index (BMI) value (p?=?0.03). CONCLUSIONS:Female subjects carrying IL28B CC-genotype are significantly more represented among Italian patients who spontaneously cleared HCV infection. In addition, among these subjects, the presence of liver steatosis does not correlate with IL28B genotype but is solely related to the occurrence of high BMI. Thus, the association between IL28B polymorphism and steatosis in chronic HCV patients requires the presence of active HCV replication to occur, while in subjects who have cleared the infection, the mechanism(s) inducing liver steatosis are independent from IL28B profile.

Dataset Information

A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population.

Publications

A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population.

Similar Datasets

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