MTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.
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ABSTRACT:
SUBMITTER: Morrison MM
PROVIDER: S-EPMC4488502 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.
Morrison Meghan M MM Young Christian D CD Wang Shan S Sobolik Tammy T Sanchez Violeta M VM Hicks Donna J DJ Cook Rebecca S RS Brantley-Sieders Dana M DM
PLoS genetics 20150701 7
Akt phosphorylation is a major driver of cell survival, motility, and proliferation in development and disease, causing increased interest in upstream regulators of Akt like mTOR complex 2 (mTORC2). We used genetic disruption of Rictor to impair mTORC2 activity in mouse mammary epithelia, which decreased Akt phosphorylation, ductal length, secondary branching, cell motility, and cell survival. These effects were recapitulated with a pharmacological dual inhibitor of mTORC1/mTORC2, but not upon g ...[more]
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