Ontology highlight
ABSTRACT:
SUBMITTER: Pitter KL
PROVIDER: S-EPMC4489138 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Pitter Kenneth L KL Tamagno Ilaria I Feng Xi X Ghosal Kaushik K Amankulor Nduka N Holland Eric C EC Hambardzumyan Dolores D
Glia 20140604 10
In response to neurodegeneration, the adult mammalian brain activates a cellular cascade that results in reactive astrogliosis and microgliosis. The mechanism through which astrocytes become reactive and the physiological consequences of their activation in response to neurodegeneration is complex. While the activation and proliferation of astrocytes has been shown to occur during massive neuronal cell death, the functional relationship between these two events has not been clearly elucidated. H ...[more]