Ontology highlight
ABSTRACT:
SUBMITTER: Zingales B
PROVIDER: S-EPMC4489481 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Zingales Bianca B Araujo Rafael Gomes Aquino RG Moreno Margoth M Franco Jaques J Aguiar Pedro Henrique Nascimento PH Nunes Solange Lessa SL Silva Marcelo Nunes MN Ienne Susan S Machado Carlos Renato CR Brandão Adeilton A
Memorias do Instituto Oswaldo Cruz 20150428 3
Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzi strains. ATP-binding cassette (ABC) transporters are involved in a variety of translocation processes and some members have been implicated in drug resistance. Here we report the characterisation of the first T. cruzi ABCG transporter gene, named TcABCG1, which is over-expresse ...[more]