Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC4489986 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Li Yiyi Y Kuscu Cem C Banach Anna A Zhang Qian Q Pulkoski-Gross Ashleigh A Kim Deborah D Liu Jingxuan J Roth Eric E Li Ellen E Shroyer Kenneth R KR Denoya Paula I PI Zhu Xiaoxia X Chen Longhua L Cao Jian J
Cancer research 20150514 13
Upregulation of matrix metalloproteinase MMP-14 (MT1-MMP) is associated with poor prognosis in cancer patients, but it is unclear how MMP-14 becomes elevated in tumors. Here, we show that miR-181a-5p is downregulated in aggressive human breast and colon cancers where its levels correlate inversely with MMP-14 expression. In clinical specimens, enhanced expression of MMP-14 was observed in cancer cells located at the invasive front of tumors where miR-181a-5p was downregulated relative to adjacen ...[more]