The comparative efficacy of lifestyle intervention and metformin by educational attainment in the Diabetes Prevention Program.

ABSTRACT:

Objective

Educational attainment is inversely associated with type 2 diabetes risk, but it is unknown whether education impacts individuals' diabetes prevention efforts. We examined the comparative efficacy of intensive lifestyle intervention and metformin by educational attainment among participants in the Diabetes Prevention Program (DPP), an ongoing U.S. multi-site trial beginning in 1996.

Methods

We studied 2,910 DPP participants randomized to receive lifestyle intervention, metformin, or placebo. Stratifying by educational attainment, diabetes incidence and relative risk reductions by treatment assignment were estimated using Cox proportional hazards regression.

Results

47% of participants had completed college and 53% had not. Compared to placebo, lifestyle part

SUBMITTER: O'Brien MJ 

PROVIDER: S-EPMC4490008 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature