Ontology highlight
ABSTRACT:
SUBMITTER: Watkins J
PROVIDER: S-EPMC4490184 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Watkins Johnathan J Weekes Daniel D Shah Vandna V Gazinska Patrycja P Joshi Shalaka S Sidhu Bhavna B Gillett Cheryl C Pinder Sarah S Vanoli Fabio F Jasin Maria M Mayrhofer Markus M Isaksson Anders A Cheang Maggie C U MC Mirza Hasan H Frankum Jessica J Lord Christopher J CJ Ashworth Alan A Vinayak Shaveta S Ford James M JM Telli Melinda L ML Grigoriadis Anita A Tutt Andrew N J AN
Cancer discovery 20150313 5
<h4>Unlabelled</h4>Triple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some of which might be caused by defects in DNA repair processes such as homologous recombination (HR). Despite this understanding, associating particular patterns of genomic instability with response to therapy has been challenging. Here, we show that allelic-imbalanced copy-number aberrations (AiCNA) are more prevalent in TNBCs that respond to platinum-based chemotherapy, thus ...[more]