Dataset Information

Epidemiological and biological determinants of Staphylococcus aureus clinical infection in New York State maximum security prisons.

ABSTRACT:

Background

Large outbreaks of Staphylococcus aureus (SA) infections have occurred in correctional facilities across the country. We aimed to define the epidemiological and microbiological determinants of SA infection in prisons to facilitate development of prevention strategies for this underserved population.

Methods

We conducted a case-control study of SA infection at 2 New York State maximum security prisons. SA-infected inmates were matched with 3 uninfected controls. Subjects had cultures taken from sites of infection and colonization (nose and throat) and were interviewed via structured questionnaire. SA isolates were characterized by spa typing. Bivariate and multivariable analyses were conducted using conditional logistic regression.

Results

Between March 2011 and January 2013, 82 cases were enrolled and matched with 246 controls. On bivariate analysis, the use of oral and topical antibiotics over the preceding 6 months was strongly associated with clinical infection (OR, 2.52; P < .001 and 4.38, P < .001, respectively). Inmates with clinical infection had 3.16 times the odds of being diabetic compared with inmates who did not have clinical infection (P < .001). Concurrent nasal and/or oropharyngeal colonization was also associated with an increased odds of infection (OR, 1.46; P = .002). Among colonized inmates, cases were significantly more likely to carry the SA clone spa t008 (usually representing the epidemic strain USA300) compared to controls (OR, 2.52; P = .01).

Conclusions

Several inmate characteristics were strongly associated with SA infection in the prison setting. Although many of these factors were likely present prior to incarceration, they may help medical staff identify prisoners for targeted prevention strategies.

SUBMITTER: Miko BA

PROVIDER: S-EPMC4490232 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Publications

Epidemiological and biological determinants of Staphylococcus aureus clinical infection in New York State maximum security prisons.

Miko Benjamin A BA Befus Montina M Herzig Carolyn T A CT Mukherjee Dhritiman V DV Apa Zoltan L ZL Bai Ruo Yu RY Tanner Joshua P JP Gage Dana D Genovese Maryann M Koenigsmann Carl J CJ Larson Elaine L EL Lowy Franklin D FD

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20150325 2

<h4>Background</h4>Large outbreaks of Staphylococcus aureus (SA) infections have occurred in correctional facilities across the country. We aimed to define the epidemiological and microbiological determinants of SA infection in prisons to facilitate development of prevention strategies for this underserved population.<h4>Methods</h4>We conducted a case-control study of SA infection at 2 New York State maximum security prisons. SA-infected inmates were matched with 3 uninfected controls. Subjects ...[more]

PMID: 25810281

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Dataset Information

Epidemiological and biological determinants of Staphylococcus aureus clinical infection in New York State maximum security prisons.

Background

Methods

Results

Conclusions

Publications

Epidemiological and biological determinants of Staphylococcus aureus clinical infection in New York State maximum security prisons.

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