Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4490553 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Li Qiming Q Xie Longxiang L Long Quanxin Q Mao Jinxiao J Li Hui H Zhou Mingliang M Xie Jianping J
Scientific reports 20150703
Antibiotics resistance poses catastrophic threat to global public health. Novel insights into the underlying mechanisms of action will inspire better measures to control drug resistance. Fluoroquinolones are potent and widely prescribed broad-spectrum antibiotics. Bacterial protein degradation pathways represent novel druggable target for the development of new classes of antibiotics. Mycobacteria proteasome accessory factor C (pafC), a component of bacterial proteasome, is involved in fluoroqui ...[more]