Ontology highlight
ABSTRACT:
SUBMITTER: Elliott TR
PROVIDER: S-EPMC4490755 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Elliott Timothy R TR Rayment Neil B NB Hudspith Barry N BN Hands Rebecca E RE Taylor Kirstin K Parkes Gareth C GC Prescott Natalie J NJ Petrovska Liljana L Hermon-Taylor John J Brostoff Jonathan J Boussioutas Alex A Mathew Christopher G CG Bustin Stephen A SA Sanderson Jeremy D JD
BMC gastroenterology 20150703
<h4>Background</h4>Abnormal handling of E. coli by lamina propria (LP) macrophages may contribute to Crohn's disease (CD) pathogenesis. We aimed to determine LP macrophage phenotypes in CD, ulcerative colitis (UC) and healthy controls (HC), and in CD, to compare macrophage phenotypes according to E. coli carriage.<h4>Methods</h4>Mucosal biopsies were taken from 35 patients with CD, 9 with UC and 18 HCs. Laser capture microdissection was used to isolate E. coli-laden and unladen LP macrophages fr ...[more]