Ontology highlight
ABSTRACT:
SUBMITTER: Collins AR
PROVIDER: S-EPMC4490864 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Collins Alan R AR Gupte Anisha A AA Ji Ruirui R Ramirez Maricela R MR Minze Laurie J LJ Liu Joey Z JZ Arredondo Magda M Ren Yuelan Y Deng Tuo T Wang Jun J Lyon Christopher J CJ Hsueh Willa A WA
Arteriosclerosis, thrombosis, and vascular biology 20120927 12
<h4>Objective</h4>To determine the impact of hematopoietic deletion of nuclear factor- (erythroid-derived 2) like 2 factor (Nrf2) on the development of atherosclerosis and liver injury in an obese, hypercholesterolemic mouse model.<h4>Methods and results</h4>Two-month-old male low-density lipoprotein receptor-deficient mice were lethally irradiated and transplanted with either wild type or Nrf2-deficient (Nrf2(-/-)) bone marrow cells. At 3 months of age, mice were placed on an obesogenic high-fa ...[more]