Ontology highlight
ABSTRACT:
SUBMITTER: Lencer WI
PROVIDER: S-EPMC4490948 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Lencer Wayne I WI DeLuca Heidi H Grey Michael J MJ Cho Jin Ah JA
Trends in immunology 20150617 7
Recent studies have linked the ER stress sensor IRE1α with the RIG-I pathway, which triggers an inflammatory response upon detection of viral RNAs. In response to ER dysfunction, IRE1α cleaves mRNA into single-strand fragments that lack markers of self, which activate RIG-I. Certain microbial products from mucosal pathogens activate this pathway by binding IRE1α directly, and the discovery that IRE1 is amplified at mucosal surfaces by gene duplication suggests an important role for IRE1 in mucos ...[more]