Ontology highlight
ABSTRACT:
SUBMITTER: Opata MM
PROVIDER: S-EPMC4491042 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Opata Michael M MM Hollifield Melissa L ML Lund Frances E FE Randall Troy D TD Dunn Robert R Garvy Beth A BA Feola David J DJ
Journal of immunology (Baltimore, Md. : 1950) 20150603 2
B cells play a critical role in the clearance of Pneumocystis. In addition to production of Pneumocystis-specific Abs, B cells are required during the priming phase for CD4(+) T cells to expand normally and generate memory. Clearance of Pneumocystis was found to be dependent on Ag specific B cells and on the ability of B cells to secrete Pneumocystis-specific Ab, as mice with B cells defective in these functions or with a restricted BCR were unable to control Pneumocystis infection. Because Pneu ...[more]