Ontology highlight
ABSTRACT:
SUBMITTER: Noh KM
PROVIDER: S-EPMC4491196 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Noh Kyung-Min KM Wang Haibo H Kim Hyunjae R HR Wenderski Wendy W Fang Fang F Li Charles H CH Dewell Scott S Hughes Stephen H SH Melnick Ari M AM Patel Dinshaw J DJ Li Haitao H Allis C David CD
Molecular cell 20150611 1
Histone modification and DNA methylation are associated with varying epigenetic "landscapes," but detailed mechanistic and functional links between the two remain unclear. Using the ATRX-DNMT3-DNMT3L (ADD) domain of the DNA methyltransferase Dnmt3a as a paradigm, we apply protein engineering to dissect the molecular interactions underlying the recruitment of this enzyme to specific regions of chromatin in mouse embryonic stem cells (ESCs). By rendering the ADD domain insensitive to histone modif ...[more]