Dataset Information

Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion.

ABSTRACT:

Objective

To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging.

Methods

One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0.

Results

CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0?L/min, and arterial pressure varied between 80 and 95?mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR ? 0.50. Dynamic perfusion scanning was possible across the range of stenosis grades. Perfusion parameters of circumflex-perfused myocardial segments were affected at increasing stenosis grades.

Conclusion

An adapted Langendorff porcine heart model is feasible in a CT environment. This model provides control over physiological parameters and may allow in-depth validation of quantitative CT perfusion techniques.

SUBMITTER: Pelgrim GJ

PROVIDER: S-EPMC4491382 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion.

Pelgrim Gert Jan GJ Das Marco M Haberland Ulrike U Slump Cees C Handayani Astri A van Tuijl Sjoerd S Stijnen Marco M Klotz Ernst E Oudkerk Matthijs M Wildberger Joachim E JE Vliegenthart Rozemarijn R

BioMed research international 20150621

<h4>Objective</h4>To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging.<h4>Methods</h4>One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve ...[more]

PMID: 26185756

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Dataset Information

Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion.

Objective

Methods

Results

Conclusion

Publications

Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion.

Similar Datasets

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