Dataset Information

Aldehyde Dehydrogenase Polymorphisms and Blood Pressure Elevation in the Japanese: A Cross-Sectional and a Longitudinal Study over 20 Years in the Shimane CoHRE Study.

ABSTRACT: Effects of a genetic polymorphism in the aldehyde dehydrogenase-2 (ALDH2) on blood pressure (BP) were investigated in a cross-sectional and a longitudinal study over 20 years on Japanese rural residents.Health examinations were held through 2006 to 2012, and 3,202 participates were recruited for this study. Among these participants, 560 individuals had medical records that were obtained in a health examination 20 years ago. Genomic DNA of participants was extracted from blood and the genotype of a polymorphism in ALDH2 was determined by the TaqMan method. Multivariate regression analyses were performed to examine association between BP and the genetic polymorphism in the ALDH2 gene.Systolic and diastolic BP were higher in the ALDH2 (?)1/(?)1 than the others (ALDH2 (?)1/(?)2 or ALDH2 (?)2/(?)2). Genetic variation of the ALDH2 gene apparently influenced drinking behavior as the number of the drinkers was significantly reduced in the ALDH2 (?)2/(?) 2 after 20 years of the observation period. This polymorphism, however, did not confer a risk for BP increase in the longitudinal observation.The present cross-sectional study confirmed a genetic effect of the ALDH2 gene on BP. In contrast, no significant effects on BP were identified in a longitudinal study, which may require a careful consideration.

SUBMITTER: Isomura M

PROVIDER: S-EPMC4491569 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Aldehyde Dehydrogenase Polymorphisms and Blood Pressure Elevation in the Japanese: A Cross-Sectional and a Longitudinal Study over 20 Years in the Shimane CoHRE Study.

Isomura Minoru M Wang Tao T Yamasaki Masayuki M Hasan Md Zahid MZ Shiwaku Kuninori K Nabika Toru T

Disease markers 20150622

<h4>Purpose</h4>Effects of a genetic polymorphism in the aldehyde dehydrogenase-2 (ALDH2) on blood pressure (BP) were investigated in a cross-sectional and a longitudinal study over 20 years on Japanese rural residents.<h4>Methods</h4>Health examinations were held through 2006 to 2012, and 3,202 participates were recruited for this study. Among these participants, 560 individuals had medical records that were obtained in a health examination 20 years ago. Genomic DNA of participants was extracte ...[more]

PMID: 26185357

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Project description:As older adults in an early stage (prefrailty) of frailty may return to a healthy state, it is necessary to examine the prevention of prefrailty. In this context, the number and types of social participation activities associated with physical prefrailty in community-dwelling older adults have remained relatively unexplored. This cross-sectional study investigates this issue by analyzing 616 participants living in Okinoshima, Shimane, a rural area of Japan, in 2019. Frailty was assessed using the 5-item frailty phenotype (unintentional weight loss, self-reported exhaustion, weakness, slow walking speed, and low physical activity). Data on social participation were obtained using a questionnaire based on participants' level of involvement with volunteer groups, sports clubs/groups, neighborhood associations, religious organizations/groups, and community elderly salons; their answers were categorized as "yes" if they answered "several times per year or more" and "no" if they answered "never." Binominal logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) of prefrailty by the number or types of social participation activities, adjusted for gender, age, body mass index, smoking, medication-taking, educational attainment, working status, and living arrangement. Of the 616 participants, 273 (44.3%) and 28 (4.5%) had prefrailty and frailty, respectively. The analysis showed that the number of social participation activities was significantly associated with lower odds of prefrailty (OR = 0.83; 95% CI, 0.74-0.94). Regarding the types of social participation, sports clubs/groups were associated with lower odds of prefrailty (OR = 0.47; 95% CI, 0.31-0.73). Participation in neighborhood associations was associated with prefrailty/frailty (OR = 0.57; 95% CI, 0.37-0.86). These results suggest that increasing the number of social participation activities or involvement in sports clubs/groups and neighborhood associations may be important to prevent physical prefrailty in the older population.

Dataset Information

Aldehyde Dehydrogenase Polymorphisms and Blood Pressure Elevation in the Japanese: A Cross-Sectional and a Longitudinal Study over 20 Years in the Shimane CoHRE Study.

Publications

Aldehyde Dehydrogenase Polymorphisms and Blood Pressure Elevation in the Japanese: A Cross-Sectional and a Longitudinal Study over 20 Years in the Shimane CoHRE Study.

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