Ontology highlight
ABSTRACT:
SUBMITTER: Isozaki H
PROVIDER: S-EPMC4491683 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Isozaki Hideko H Takigawa Nagio N Kiura Katsuyuki K
Cancers 20150430 2
The discovery of an echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene led to improved clinical outcomes in patients with lung cancer after the development of the first ALK-targeting agent, crizotinib. Some second-generation ALK tyrosine kinase inhibitors (TKIs), which might be more potent than crizotinib or effective on crizotinib-resistant patients, have been developed. Although these ALK-TKIs show an excellent response initially, most patients ...[more]