Ontology highlight
ABSTRACT:
SUBMITTER: Kanekura K
PROVIDER: S-EPMC4492519 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Kanekura Kohsuke K Ma Xiucui X Murphy John T JT Zhu Lihua J LJ Diwan Abhinav A Urano Fumihiko F
Science signaling 20150623 382
The endoplasmic reticulum (ER) has emerged as a critical regulator of cell survival. IRE1 is a transmembrane protein with kinase and RNase activities that is localized to the ER and that promotes resistance to ER stress. We showed a mechanism by which IRE1 conferred protection against ER stress-mediated cell death. IRE1 signaling prevented ER membrane permeabilization mediated by Bax and Bak and cell death in cells experiencing ER stress. Suppression of IRE1 signaling triggered by its kinase act ...[more]