Dataset Information

Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race.

ABSTRACT:

Background

Regular physical activities have a positive effect on the muscular skeletal system but overstrenuous exercise may be different. Transiently suppressed bone formation and increased bone resorption after participation in a 246-km ultradistance race has been demonstrated.

Purpose

The aim of this study was to analyze effects of the Spartathlon race on novel musculoskeletal markers.

Methods

Venous blood samples were obtained before and immediately after the race from 19 participants of the Spartathlon. From 9 runners who were available 3 days after the start blood was drawn for a third time. Serum levels of myostatin, an inhibitor of myogenic differentiation, and its opponent follistatin as well as sclerostin and dickkopf-1, both of them inhibitors of the wnt signaling pathway, and markers of bone turnover were determined.

Results

Serum levels of myostatin were significantly higher after the race. Serum follistatin only showed a transient increase. Sclerostin levels did not significantly differ before and after the race, whereas dickkopf-1 levels were significantly decreased. At follow-up a decrement of sclerostin and dickkopf-1 levels was seen. Serum cathepsin K levels did not change.

Conclusion

The increase of serum levels of myostatin appears to reflect muscle catabolic processes induced by overstrenuous exercise. After the short-term uncoupling of bone turnover participation in an ultradistance race seems to initiate a long-term positive effect on bone indicated by the low-level inhibition of the Wnt/?-catenin signaling pathway.

SUBMITTER: Kerschan-Schindl K

PROVIDER: S-EPMC4493015 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race.

Kerschan-Schindl Katharina K Thalmann Markus M MM Weiss Elisabeth E Tsironi Maria M Föger-Samwald Ursula U Meinhart Johann J Skenderi Katerina K Pietschmann Peter P

PloS one 20150706 7

<h4>Background</h4>Regular physical activities have a positive effect on the muscular skeletal system but overstrenuous exercise may be different. Transiently suppressed bone formation and increased bone resorption after participation in a 246-km ultradistance race has been demonstrated.<h4>Purpose</h4>The aim of this study was to analyze effects of the Spartathlon race on novel musculoskeletal markers.<h4>Methods</h4>Venous blood samples were obtained before and immediately after the race from ...[more]

PMID: 26147574

Similar Datasets

Project description:This comprehensive case analysis aimed to identify the features enabling a runner to achieve championship in 24-h ultramarathon (UM) races. A 36-year-old, multiple medalist of the World Championships in 24-h running, was assessed before, one and 10 days after a 24-h run. Results of his extensive laboratory and cardiological diagnostics with transthoracic echocardiography (TTE) and a one-time cardiopulmonary exercise test (CPET) were analyzed. After 12 h of running (approximately 130 km), the athlete experienced an increasing pain in the right knee. His baseline clinical data were within the normal range. High physical efficiency in CPET (VO2max 63 mL/kg/min) was similar to the average achieved by other ultramarathoners who had significantly worse results. Thus, we also performed genetic tests and assessed his psychological profile, body composition, and markers of physical and mental stress (serotonin, cortisol, epinephrine, prolactin, testosterone, and luteinizing hormone). The athlete had a mtDNA haplogroup H (HV0a1 subgroup, belonging to the HV cluster), characteristic of athletes with the highest endurance. Psychological studies have shown high and very high intensity of the properties of individual scales of the tools used mental resilience (62-100% depending on the scale), openness to experience (10th sten), coherence (10th sten), positive perfectionism (100%) and overall hope for success score (10th sten). The athlete himself considers the commitment and mental support of his team to be a significant factor of his success. Body composition assessment (%fat 13.9) and the level of stress markers were unremarkable. The tested athlete showed a number of features of the champions of ultramarathon runs, such as: inborn predispositions, mental traits, level of training, and resistance to pain. However, none of these features are reserved exclusively for "champions". Team support's participation cannot be underestimated. The factors that guarantee the success of this elite 24-h UM runner go far beyond physiological and psychological explanations. Further studies are needed to identify individual elements of the putative "mosaic theory of being a champion".

Dataset Information

Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race.

Background

Purpose

Methods

Results

Conclusion

Publications

Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race.

Similar Datasets

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