Structure and Assembly of TP901-1 Virion Unveiled by Mutagenesis.
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ABSTRACT:
SUBMITTER: Stockdale SR
PROVIDER: S-EPMC4493119 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Structure and Assembly of TP901-1 Virion Unveiled by Mutagenesis.
Stockdale Stephen R SR Collins Barry B Spinelli Silvia S Douillard François P FP Mahony Jennifer J Cambillau Christian C van Sinderen Douwe D
PloS one 20150706 7
Bacteriophages of the Siphoviridae family represent the most abundant viral morphology in the biosphere, yet many molecular aspects of their virion structure, assembly and associated functions remain to be unveiled. In this study, we present a comprehensive mutational and molecular analysis of the temperate Lactococcus lactis-infecting phage TP901-1. Fourteen mutations located within the structural module of TP901-1 were created; twelve mutations were designed to prevent full length translation ...[more]
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