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Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature.

ABSTRACT: We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.

SUBMITTER: Khattab MH

PROVIDER: S-EPMC4493308 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature.

Khattab Mohamed H MH Marciscano Ariel E AE Lo Simon S SS Lim Michael M Laterra John J JJ Kleinberg Lawrence R LR Redmond Kristin J KJ

Case reports in oncological medicine 20150623

We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and comp ...[more]

PMID: 26199775

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Extracranial metastasis of glioblastoma with genomic analysis: a case report and review of the literature.

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