Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Sanchez JA
PROVIDER: S-EPMC4494002 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Gomez-Sanchez Jose A JA Carty Lucy L Iruarrizaga-Lejarreta Marta M Palomo-Irigoyen Marta M Varela-Rey Marta M Griffith Megan M Hantke Janina J Macias-Camara Nuria N Azkargorta Mikel M Aurrekoetxea Igor I De Juan Virginia Gutiérrez VG Jefferies Harold B J HB Aspichueta Patricia P Elortza Félix F Aransay Ana M AM Martínez-Chantar María L ML Baas Frank F Mato José M JM Mirsky Rhona R Woodhoo Ashwin A Jessen Kristján R KR
The Journal of cell biology 20150701 1
Although Schwann cell myelin breakdown is the universal outcome of a remarkably wide range of conditions that cause disease or injury to peripheral nerves, the cellular and molecular mechanisms that make Schwann cell-mediated myelin digestion possible have not been established. We report that Schwann cells degrade myelin after injury by a novel form of selective autophagy, myelinophagy. Autophagy was up-regulated by myelinating Schwann cells after nerve injury, myelin debris was present in autop ...[more]