Ontology highlight
ABSTRACT:
SUBMITTER: Klare K
PROVIDER: S-EPMC4494010 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Klare Kerstin K Weir John R JR Basilico Federica F Zimniak Tomasz T Massimiliano Lucia L Ludwigs Nina N Herzog Franz F Musacchio Andrea A
The Journal of cell biology 20150629 1
Kinetochores are multisubunit complexes that assemble on centromeres to bind spindle microtubules and promote faithful chromosome segregation during cell division. A 16-subunit complex named the constitutive centromere-associated network (CCAN) creates the centromere-kinetochore interface. CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. The role of CENP-C in CCAN organization, on the other hand, had ...[more]