Mechanistic studies of uncatalyzed and ruthenium(III)-catalyzed oxidation of the antibiotic drug chloramphenicol by hexacyanoferrate(III) in aqueous alkaline medium: a comparative kinetic study.

ABSTRACT:

Abstract

The kinetics of oxidation of the antibiotic drug chloramphenicol (CHP) by hexacyanoferrate(III) (HCF) has been investigated spectrophotometrically both in the absence and presence of ruthenium(III) catalyst in aqueous alkaline medium at 25 °C and at constant ionic strength of 1.10 mol dm^-3. The stoichiometry is identical in both cases, i.e. [CHP]/[HCF] = 1:2. The oxidation products were identified by TLC and spectral studies such as GC-MS, IR, and ¹H NMR. In both catalyzed and uncatalyzed reactions, the order with respect to the concentration of HCF is unity, whereas the order with respect to the concentration of CHP and the concentration of OH^- is less than unity over the concentration range studied. The order with respect to the concentra

SUBMITTER: Meti MD 

PROVIDER: S-EPMC4494844 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature