Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth.
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ABSTRACT:
SUBMITTER: Hu J
PROVIDER: S-EPMC4494930 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth.
Hu Jianguo J Meng Ying Y Yu Tinghe T Hu Lina L Mao Ming M
Oncotarget 20150501 14
Ubiquitin E3 ligase MARCH7 is involved in T cell proliferation and neuronal development. We found that expression of MARCH7 was higher in ovarian cancer tissues than normal ovarian tissues. Silencing MARCH7 decreased cell proliferation, migration, and invasion. Ectopic expression of MARCH7 increased cell proliferation, migration and invasion. Silencing MARCH7 prevented ovarian cancer growth in mice. Silencing MARCH7 inhibited NFkB and Wnt/β-catenin pathway. In agreement, ectopically expressed MA ...[more]
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