Ontology highlight
ABSTRACT:
SUBMITTER: Bull-Hansen B
PROVIDER: S-EPMC4494949 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Bull-Hansen Bente B Berstad Maria B MB Berg Kristian K Cao Yu Y Skarpen Ellen E Fremstedal Ane Sofie AS Rosenblum Michael G MG Peng Qian Q Weyergang Anette A
Oncotarget 20150501 14
HER2-targeted therapy has been shown to have limited efficacy in ovarian cancer despite frequent overexpression of this receptor. Photochemical internalization (PCI) is a modality for cytosolic drug delivery, currently undergoing clinical evaluation. In the present project we studied the application of PCI in combination with the HER2-targeted recombinant fusion toxin, MH3-B1/rGel, for the treatment of ovarian cancer. The SKOV-3 cell line, resistant to trastuzumab- and MH3-B1/rGel- monotherapy, ...[more]