Ontology highlight
ABSTRACT:
SUBMITTER: Barfeld SJ
PROVIDER: S-EPMC4494960 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Barfeld Stefan J SJ Fazli Ladan L Persson Margareta M Marjavaara Lisette L Urbanucci Alfonso A Kaukoniemi Kirsi M KM Rennie Paul S PS Ceder Yvonne Y Chabes Andrei A Visakorpi Tapio T Mills Ian G IG
Oncotarget 20150501 14
The androgen receptor is a key transcription factor contributing to the development of all stages of prostate cancer (PCa). In addition, other transcription factors have been associated with poor prognosis in PCa, amongst which c-Myc (MYC) is a well-established oncogene in many other cancers. We have previously reported that the AR promotes glycolysis and anabolic metabolism; many of these metabolic pathways are also MYC-regulated in other cancers. In this study, we report that in PCa cells de n ...[more]