Ontology highlight
ABSTRACT:
SUBMITTER: Ofengeim D
PROVIDER: S-EPMC4494996 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Ofengeim Dimitry D Ito Yasushi Y Najafov Ayaz A Zhang Yaoyang Y Shan Bing B DeWitt Judy Park JP Ye Juanying J Zhang Xumin X Chang Ansi A Vakifahmetoglu-Norberg Helin H Geng Jiefei J Py Benedicte B Zhou Wen W Amin Palak P Berlink Lima Jonilson J Qi Chunting C Yu Qiang Q Trapp Bruce B Yuan Junying J
Cell reports 20150301 11
Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine implicated in MS, can activate necroptosis, a necrotic cell death pathway regulated by RIPK1 and RIPK3 under caspase-8-deficient conditions. Here, we demonstrate defective caspase-8 activation, as well as activation of RIPK1, RIPK3, and MLKL, the hallmark mediators of necroptosis, in the cortical le ...[more]