Ontology highlight
ABSTRACT:
SUBMITTER: Zamudio N
PROVIDER: S-EPMC4495397 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Zamudio Natasha N Barau Joan J Teissandier Aurélie A Walter Marius M Borsos Maté M Servant Nicolas N Bourc'his Déborah D
Genes & development 20150601 12
DNA methylation is essential for protecting the mammalian germline against transposons. When DNA methylation-based transposon control is defective, meiotic chromosome pairing is consistently impaired during spermatogenesis: How and why meiosis is vulnerable to transposon activity is unknown. Using two DNA methylation-deficient backgrounds, the Dnmt3L and Miwi2 mutant mice, we reveal that DNA methylation is largely dispensable for silencing transposons before meiosis onset. After this, it becomes ...[more]