Ontology highlight
ABSTRACT:
SUBMITTER: Schiel JA
PROVIDER: S-EPMC4495918 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Schiel John A JA Simon Glenn C GC Zaharris Chelsey C Weisz Julie J Castle David D Wu Christine C CC Prekeris Rytis R
Nature cell biology 20120923 10
The final cytokinesis event involves severing of the connecting intercellular bridge (ICB) between daughter cells. FIP3-positive recycling endosomes (FIP3 endosomes) and ESCRT complexes have been implicated in mediating the final stages of cytokinesis. Here we analyse the spatiotemporal dynamics of the actin cytoskeleton, FIP3-endosome fusion and ESCRT-III localization during cytokinesis to show that the ICB narrows by a FIP3-endosome-mediated secondary ingression, whereas the ESCRT-III complex ...[more]