Dataset Information

Outbreak of febrile illness caused by coxsackievirus A4 in a nursery school in Beijing, China.

ABSTRACT: Coxsackievirus A4 (CV-A4) is classified as human enterovirus A according to its serotype. CV-A4, an etiological agent of hand, foot, and mouth disease, affects children worldwide and can circulate in closed environments such as schools and hospitals for long periods.An outbreak of febrile illness at a nursery school in Beijing, China, was confirmed to be caused by CV-A4. Phylogenetic analysis of the complete genome of the isolated strain showed that the virus belongs to the same cluster as the predominant CV-A4 strain in China. This outbreak was controlled by effective measures.The early identification of the pathogen and timely intervention may be the most critical factors in controlling an outbreak caused by CV-A4 in a preschool.

SUBMITTER: Li JS

PROVIDER: S-EPMC4495935 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Outbreak of febrile illness caused by coxsackievirus A4 in a nursery school in Beijing, China.

Li Jin-Song JS Dong Xiao-Gen XG Qin Meng M Xie Zhi-Ping ZP Gao Han-Chun HC Yang Jun-Yong JY Yang Xiao-Xin XX Li Dan-Di DD Li Jie J Duan Zhao-Jun ZJ

Virology journal 20150618

<h4>Background</h4>Coxsackievirus A4 (CV-A4) is classified as human enterovirus A according to its serotype. CV-A4, an etiological agent of hand, foot, and mouth disease, affects children worldwide and can circulate in closed environments such as schools and hospitals for long periods.<h4>Findings</h4>An outbreak of febrile illness at a nursery school in Beijing, China, was confirmed to be caused by CV-A4. Phylogenetic analysis of the complete genome of the isolated strain showed that the virus ...[more]

PMID: 26084565

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Project description:BACKGROUND:On 7th June, 2018, a primary school in Beijing, China notified Shunyi CDC of an outbreak of acute respiratory disease characterized by fever and cough among students and resulting in nine hospitalization cases during the preceding 2?weeks. We started an investigation to identify the etiologic agent, find additional cases, develop and implement control measures. METHODS:We defined probable cases as students, teachers and other staffs in the school developed fever (T???37.5?°C) with cough or sore throat; or a diagnosis of pneumonia during May 1-June 31, 2018. Confirmed cases were probable cases with Mycoplasma pneumoniae detected in oropharyngeal (OP) swabs by quantitative real-time polymerase chain reaction (qPCR). We searched case by reviewing school absenteeism records and interviewing students, teachers and staff in this school. Oropharyngeal swabs were collected from symptomatic students. Two qPCR) assay, a duplex qPCR assay, and sequencing were performed to determine the pathogen, genotype and macrolide resistance at the gene level, respectively. RESULTS:From May 1st to June 31st, 2018, we identified 55 cases (36 probable and 19 confirmed), of whom 25 (45%) were hospitalized for complications. All cases were students, none of the teachers and other staffs in the school were with similar symptoms. The attack rate (AR) was 3.9% (55/1398) for all students. The cases were mainly male (58%), with an age range of 7-8?years (median: 7?years). 72% (18/25) of inpatients had radiograph findings consistent with pneumonia, and some cases were hospitalized for up to 4?weeks. Pathogen detection results indicated that Mycoplasma pneumonia (M. pneumoniae) P1 type 1 was the causative agent in this outbreak, and the strain harbored one point mutation of A to G at position 2063. CONCLUSIONS:The infections by macrolide-resistant M. pneumoniae are not always mild and pneumonia was common and M. pneumoniae could causes serious complications which require long-term hospitalization. In the future infectious disease prevention and control practice, M. pneumoniae should be paid more attention. It is necessary to establish and improve the pathogen and drug resistance surveillance system in order to prevent and control such mutated strains of M. pneumoniae from causing future outbreaks or epidemics in China.

Dataset Information

Outbreak of febrile illness caused by coxsackievirus A4 in a nursery school in Beijing, China.

Publications

Outbreak of febrile illness caused by coxsackievirus A4 in a nursery school in Beijing, China.

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