Ontology highlight
ABSTRACT:
SUBMITTER: Inman M
PROVIDER: S-EPMC4495957 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Inman Martyn M Visconti Andrea A Yan Chao C Siegel David D Ross David D Moody Christopher J CJ
Organic & biomolecular chemistry 20140701 27
An important determinant of the growth inhibitory activity of indolequinones against pancreatic cancer cells is substitution on the 2-position with 2-unsubstituted derivatives being markedly more potent. A series of indolequinones bearing a range of substituents on nitrogen and at the indolylcarbinyl position was prepared by copper(II)-mediated reaction of bromoquinones and enamines, followed by functional group interconversions. The compounds were then assayed for their ability to inhibit the g ...[more]