The Relationship between Runs of Homozygosity and Inbreeding in Jersey Cattle under Selection.

ABSTRACT: Inbreeding is often an inevitable outcome of strong directional artificial selection but on average it reduces population fitness with increased frequency of recessive deleterious alleles. Runs of homozygosity (ROH) representing genomic autozygosity that occur from mating between selected and genomically related individuals may be able to reveal the regions affecting fitness. To examine the influence of genomic autozygosity on fitness, we used a genome-wide association test to evaluate potential negative correlations between ROH and daughter pregnancy rate (DPR) or somatic cell score (SCS) in US Jersey cattle. In addition, relationships between changes of local ROH and inbreeding coefficients (F) were assessed to locate genomic regions with increased inbreeding. Despite finding some decrea

SUBMITTER: Kim ES 

PROVIDER: S-EPMC4496098 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature