Ontology highlight
ABSTRACT:
SUBMITTER: Gupta J
PROVIDER: S-EPMC4496165 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Gupta Jalaj J Igea Ana A Papaioannou Marilena M Lopez-Casas Pedro Pablo PP Llonch Elisabet E Hidalgo Manuel M Gorgoulis Vassilis G VG Nebreda Angel R AR
Oncotarget 20150401 11
Colorectal cancer is a major health problem and the second cause of cancer related death in western countries. Signaling pathways that control tissue homeostasis are often deregulated during tumorigenesis and contribute to tumor development. Studies in mouse models have shown that the p38 MAPK pathway regulates homeostasis in colon epithelial cells but also plays an important role in colon tumor maintenance. In this study, we have investigated the role of p38 MAPK signaling in patient-derived xe ...[more]