The stromal genome heterogeneity between breast and prostate tumors revealed by a comparative transcriptomic analysis.
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ABSTRACT:
SUBMITTER: He K
PROVIDER: S-EPMC4496176 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
The stromal genome heterogeneity between breast and prostate tumors revealed by a comparative transcriptomic analysis.
He Kan K Lv Wenwen W Zheng Dongni D Cheng Fei F Zhou Tao T Ye Shoudong S Ban Qian Q Ying Qilong Q Huang Bei B Chen Lei L Wu Guohua G Liu Dahai D
Oncotarget 20150401 11
Stromal microenvironment increases tumor cell survival, proliferation and migration, and promotes angiogenesis. In order to provide comprehensive information on the stromal heterogeneity of diverse tumors, here we employed the microarray datasets of human invasive breast and prostate cancer-associated stromals and applied Gene Set Enrichment Analysis (GSEA) to compare the gene expression profiles between them. As a result, 8 up-regulated pathways and 73 down-regulated pathways were identified in ...[more]
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