CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.
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ABSTRACT:
SUBMITTER: Cerqueira OL
PROVIDER: S-EPMC4496225 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.
Cerqueira Otto L D OL Truesdell Peter P Baldassarre Tomas T Vilella-Arias Santiago A SA Watt Kathleen K Meens Jalna J Chander Harish H Osório Cynthia A B CA Soares Fernando A FA Reis Eduardo M EM Craig Andrew W B AW
Oncotarget 20150401 11
Signaling via epidermal growth factor receptor (EGFR) and Src kinase pathways promote triple-negative breast cancer (TNBC) cell invasion and tumor metastasis. Here, we address the role of Cdc42-interacting protein-4 (CIP4) in TNBC metastasis in vivo, and profile CIP4 expression in human breast cancer patients. In human TNBC cells, CIP4 knock-down (KD) led to less sustained activation of Erk kinase and impaired cell motility compared to control cells. This correlated with significant defects in 3 ...[more]
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